Barry J Hoffer Selected Research

phenserine

1/2020	(-)-Phenserine tartrate (PhenT) as a treatment for traumatic brain injury.
10/2019	(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice.
9/2019	(-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and Behavioral Impairments Induced by Traumatic Brain Injury in Mice.
9/2017	Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine.
1/2016	Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Barry J Hoffer Research Topics

Disease

23	Parkinson Disease (Parkinson's Disease) 01/2022 - 01/2002
22	Traumatic Brain Injuries (Traumatic Brain Injury) 04/2021 - 09/2011
13	Stroke (Strokes) 04/2022 - 07/2002
12	Neuroinflammatory Diseases 04/2022 - 01/2016
9	Cognitive Dysfunction 11/2022 - 01/2013
9	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2011
9	Brain Concussion (Cerebral Concussion) 01/2020 - 10/2013
9	Brain Injuries (Brain Injury) 01/2019 - 02/2009
6	Ischemia 01/2011 - 02/2003
5	Type 2 Diabetes Mellitus (MODY) 01/2020 - 01/2009
4	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 04/2022 - 07/2002
4	Inflammation (Inflammations) 04/2022 - 01/2017
4	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2021 - 01/2011
3	Dyskinesias (Dyskinesia) 01/2022 - 08/2015
3	Wounds and Injuries (Trauma) 10/2021 - 02/2005
3	Gliosis 07/2021 - 03/2015
3	Nervous System Diseases (Neurological Disorders) 01/2019 - 10/2018
2	Ischemic Stroke 01/2020 - 01/2019
2	Craniocerebral Trauma (Head Injury) 01/2020 - 10/2018
2	Contusions 09/2019 - 01/2019
2	Brain Ischemia (Cerebral Ischemia) 01/2019 - 07/2002
2	Seizures (Absence Seizure) 02/2018 - 01/2016
2	Blast Injuries 01/2016 - 02/2014
2	Mental Disorders (Mental Disorder) 03/2012 - 08/2006
2	Huntington Disease (Huntington's Disease) 01/2011 - 11/2002
2	Parkinsonian Disorders (Parkinsonism) 01/2009 - 03/2007
2	Infarction (Infarctions) 03/2007 - 07/2002
1	Neoplasms (Cancer) 04/2022
1	Disease Progression 04/2021
1	Hypokinesia (Bradykinesia) 01/2021
1	Brain Contusion 01/2020
1	Obesity 01/2020
1	Multiple System Atrophy 01/2019
1	Multiple Sclerosis 01/2019
1	Insulin Resistance 01/2017
1	Body Weight (Weight, Body) 01/2017

Drug/Important Bio-Agent (IBA)

15	Dopamine (Intropin)FDA LinkGeneric 01/2022 - 08/2006
10	Pharmaceutical PreparationsIBA 04/2022 - 08/2009
10	Exenatide (Byetta)FDA Link 01/2020 - 01/2013
9	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2002
6	pomalidomideIBA 04/2022 - 01/2016
6	Glucagon-Like Peptide 1 (GLP 1)IBA 04/2021 - 02/2014
6	Glucagon-Like Peptide-1 ReceptorIBA 01/2017 - 01/2009
5	SynucleinsIBA 04/2022 - 01/2020
5	phenserineIBA 01/2020 - 01/2016
5	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 09/2011 - 01/2002
4	CytokinesIBA 01/2020 - 01/2019
4	Glutamic Acid (Glutamate)FDA Link 01/2020 - 07/2002
4	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2009
4	Oxidopamine (6 Hydroxydopamine)IBA 01/2020 - 01/2005
3	Levodopa (L Dopa)FDA LinkGeneric 01/2022 - 08/2015
3	Messenger RNA (mRNA)IBA 01/2020 - 06/2006
3	pifithrinIBA 01/2020 - 05/2009
3	Neuroprotective AgentsIBA 01/2020 - 01/2019
3	Peptides (Polypeptides)IBA 01/2020 - 01/2016
3	3,6'-dithiothalidomideIBA 01/2019 - 09/2011
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 01/2005
3	Blood Glucose (Blood Sugar)IBA 01/2017 - 01/2009
3	Explosive Agents (Explosives)IBA 02/2014 - 12/2011
3	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 02/2009 - 01/2005
3	Transforming Growth Factor beta (TGF-beta)IBA 06/2006 - 01/2005
2	Amyloid (Amyloid Fibrils)IBA 11/2022 - 04/2021
2	AntioxidantsIBA 10/2021 - 10/2018
2	Immunomodulating AgentsIBA 07/2021 - 01/2020
2	Thalidomide (Thalomid)FDA Link 04/2021 - 01/2019
2	tartaric acid (tartrate)FDA Link 01/2020 - 10/2019
2	ChemokinesIBA 01/2020 - 08/2009
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 09/2019 - 01/2016
2	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2019 - 02/2014
2	IncretinsIBA 01/2019 - 10/2013
2	Nicotine FDA Link 10/2018 - 02/2018
2	Delayed-Action PreparationsIBA 09/2018 - 07/2018
2	Kainic Acid (Kainate)IBA 02/2018 - 01/2016
2	Levetiracetam (Keppra)FDA LinkGeneric 02/2018 - 01/2016
2	Cysteine (L-Cysteine)FDA Link 09/2017 - 01/2014
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2015 - 09/2011
2	Mitochondrial DNA (mtDNA)IBA 10/2014 - 11/2010
2	NeurotoxinsIBA 02/2009 - 01/2005
2	Protein Isoforms (Isoforms)IBA 03/2007 - 06/2006
2	Nerve Growth Factors (Neurotrophins)IBA 01/2007 - 01/2002
2	Bone Morphogenetic Protein 7IBA 02/2005 - 02/2003
1	ImidesIBA 04/2022
1	Tetrabenazine (Nitoman)FDA Link 01/2022
1	phthalimidineIBA 04/2021
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2021
1	SomanIBA 01/2020
1	BenserazideIBA 01/2020
1	Nerve AgentsIBA 01/2020
1	Glucagon (Glukagon)FDA Link 01/2020
1	fluoro-jade CIBA 01/2020
1	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	Annexin A5IBA 01/2020
1	AntibodiesIBA 01/2019
1	fluoro jadeIBA 01/2019
1	Surface-Active Agents (Surfactants)IBA 01/2019
1	SynaptophysinIBA 01/2017

Therapy/Procedure

3	Therapeutics 04/2022 - 01/2011
2	Denervation 08/2015 - 03/2007
1	Intravenous Injections 07/2021